Author/Authors :
Alirezaei, Amirhesam Clinical Research and Development Center at Shahid Modarres Hospital - Department of Nephrology - Shahid Beheshti University of Medical Sciences , Argani, Hassan Clinical Research and Development Center at Shahid Modarres Hospital - Department of Nephrology - Shahid Beheshti University of Medical Sciences , Asgharpour, Masoumeh Department of Nephrology - Rouhani Hospital of Medical Sciences, Babol, Iran , Bahadorimonfared, Ayad Department of Health & Community Medicine - Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Bakhtiyari, Mahmood Department of Community Medicine - School of Medicine - Alborz University of Medical Sciences, Karaj, Iran
Abstract :
Allopurinol is an inhibitor of xanthine oxidase (XO) enzyme. This drug is a reducer of uric acid in the body and one of the golden drugs with worldwide administration. XO is an important biological source of free radical generation. Allopurinol as an antioxidant, has direct and indirect antioxidant activity on these free radicals such as hydroxyl radical and superoxide anion. The purpose of this paper is to determine the impact of allopurinol on some aspects of renal disturbances such as renal ischemia/reperfusion injury (IRI), nephrotoxicity and contrast-induced nephropathy (CIN).
Keywords :
Allopurinol , Free radicals , Hyperuricemia , Renal ischemia
