Author/Authors :
Zand, Sanaz Department of Research - Kaviani Breast Disease Institute (KBDI), Tehran , Jalili, Roghayye Department of Surgery - Tehran University of Medical Sciences (TUMS), Tehran , Emami Razavi, Hasan Department of Surgery - Tehran University of Medical Sciences (TUMS), Tehran , Najafi, Massoome Department of Surgery - Tehran University of Medical Sciences (TUMS), Tehran , Kaviani, Ahmad Department of Research - Kaviani Breast Disease Institute (KBDI), Tehran
Abstract :
Background: Warfarin induced breast necrosis is a rare complication of oral
anticoagulant therapy. Although it can be related to protein C, S, and antithrombin
III deficiency; the pathogenesis of necrosis is still unknown.
Case presentation: We report a case of a 38-year-old woman with extensive left
breast necrosis after receiving warfarin for treatment of deep vein thrombosis.
Simple mastectomy was performed and the wound was closed secondarily with an
abdominal advancement flap. Rivaroxaban was prescribed after discontinuation of
warfarin.
Conclusion: Although breast necrosis following warfarin usage is uncommon,
it should be considered in women presenting with breast symptoms after initiation
of warfarin. Early diagnosis and appropriate management are essential to prevent
extensive loss of breast tissue.
Keywords :
Warfarin , breast necrosis , breast gangrene , oral anticoagulant therapy
