Effects of antioxidants on xenobiotics-induced nephrotoxicity

Kidney is a primary organ for excretion of endogenous and exogenous chemicals. Therefore, all toxic chemicals which are eliminated via urine pass through this organ. It also contains xenobiotics metabolizing enzymes, capable of metabolizing toxic xenobiotics. Increasing evidence supports the view that generation of oxidative stress in situ at least in part is responsible for renal failure. In animal models administration of various antioxidants protected kidney against environmental toxic chemicals. However, further studies are needed for the clinical benefit of antioxidants intervention in renal diseases.