Association of interdialytic weight gain and glycosylated hemoglobin in chronic hemodialysis patients

Introduction: The most common cause of mortality among chronic hemodialysis (HD) patients is cardiovascular disease. Hypervolemia is an important risk factor for hypertension and cardiovascular mortality in HD patients that include chronic volume overload and interdialytic weight gain (IDWG). Objectives: The objective of this study is to assess the role of blood glucose in IDWG. Patients and Methods: In this cross-sectional study we enrolled 231 adult chronic HD patients. Patients with congestive heart failure, hypoalbuminemia, cirrhosis, hypothyroidism and recent blood transfusion were excluded. We weighted patients at the end of dialysis and before initiation the next dialysis in midweek dialysis sessions. Glycosylated hemoglobin (HbA1C) was measured in all patients. Patients were divided into three groups according HbA1C levels (<6%, 6-7%, >7%). Additionally IDWG of three groups was compared using analysis of variance (ANOVA) method. Results: HbA1C was <6% in 158 (68%) patients (group A), 6-7% in 40 (17%) patients (group B) and >7% in 33 (14%) patients (group C). Mean IDWG was 2.44 kg in group A, 2.25 kg in group B and 2.71 kg in group C. In this study, no significant difference of IDWG in patients with different values of HbA1C was detected (P = .206). Conclusion: Our study showed that blood glucose level had no significant role in IDWG in chronic HD patients.