Relationship of serum C-reactive protein and uric acid concentration with proportion of albuminuria in patients with type 2 diabetes mellitus

Introduction: Prevalence of diabetes and its complications will be considerably increased in the future. This study focused on the correlation of some laboratory parameters with prevalence and severity of diabetic nephropathy which is the main cause of chronic renal failure (CRF) in our country. Objectives: Regarding the importance of diabetic nephropathy and lack of studies on the effect of serum C-reactive protein (CRP) and uric acid on albuminuria and its severity, the current study was designed. Methods: Through an analytic cross-sectional design, 200 type 2 diabetes mellitus (T2DM) cases were recruited between 2014 and 2015. Blood samples were drawn after 12 hours of starving to measure parameters including serum levels of CRP, triglyceride (TG) and highdensity lipoprotein cholesterol (HDL-C), cholesterol, Low-density lipoprotein (LDL-C), fasting blood sugar (FBS), and Hb-A1C. Albuminuria was assessed by collecting participants’ 24 hours urine. Results: Macro-albuminuria correlated with high serum uric acid (SUA) (odds ratio [OR]= 1.3) and high serum CRP (OR = 1.2) among diabetic patients. Both markers represented significant correlation with albuminuria. Logistic regression test confirmed the mentioned correlation when confounding factors were eliminated. Conclusion: It seems that uric acid and CRP levels in serum are the most reliable parameters studied by the current study to predict life-threatening diabetic consequences like cardiovascular and chronic kidney disease in patients with type II diabetes mellitus.