Synthesis and antimicrobial evaluation of bis imidazolidinone assembled dihydropyridine ethoxyphthalimide derivatives

In the present investigation there is an easy access to a series of imidazole containing dihydropyridine attached alkoxyphthalimide moiety in a single molecule. Schiff bases (3a-c) of the compound 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarbohydrazide (2) was prepared by refluxing it with substituted benzaldehydes which in turn was obtained by condensation of benzaldehyde with ethylaectoacetate followed by treatment of hydrazine hydrate. Condensation of (3a-c) with bromoethoxyphthalimide yielded compound (4a-c). Further cyclization of (4a-c) to the multinucleated final compound (5a-c) was achieved by treating this with glycine in a mixed solvent. Structure of compounds was confirmed by analytical, spectral data & chemical tests. Six of these compounds have been screened for antimicrobial screening against 4 bacterial and 2 fungal pathogenic strains. Half of the compounds showed appreciable activity.