BF3.SiO2: an efficient catalyst for the synthesis of tetrasubstituted pyrrole derivatives

Silica supported boron trifluoride (BF3.SiO2) was prepared by boron trifluoride diethyl etherate and powder of silicon dioxide. This catalyst was used for the synthesis of tetrasubstituted pyrrole derivatives by condensation of amine, aldehyde, 1, 3-dicarbonyl compound and nitromethane. Silica supported boron trifluoride is readily available and reusable catalyst which results good to excellent yield of products in the proposed reaction. After each run, the catalyst residue was washed with chloroform and reused. This reaction was considered by different solvents at room temperature and the reflux condition. The best conditions can be obtained using BF3.SiO2 under solvent free condition at room temperature within 90 min.