Title of article :
New route for the synthesis of thieno[2, 3- d]pyrimidine derivatives
Author/Authors :
Shaabani, Tayyebe Department of Chemistry - Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran , Nikpour, Mohsen Department of Chemistry - Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran
Abstract :
Condensation of ethylthioglycolate with 2,4-dichloro-6-phenylpyrimidine-5-carbonitrile afforded ethyl 5-amino-2-chloro-4-phenylthieno[2,3-d]pyrimidine-6-carboxylate in alkalineethanol. Chlorine atom of the latter compound was easily replaced by secondary amines in ethanol to achieve a new group of ethyl5-amino -4-phenylthieno[2,3-d]pyrimidine-6-carboxylate derivatives.
Keywords :
Ethylthioglycolate , 2,4-Dichloro-6-phenylpyrimidine-5-carbonitrile , Ethyl-5-amino-2-chloro-4-phenylthieno[2,3-d]pyrimidine-6-carboxylate , Substitution , Cyclocondensation
Journal title :
Astroparticle Physics
