Title of article :
An efficient protocol for the synthesis of tetrahydropyrimidine-5-carboxamides: La(NO3)3.6H2O as a convenient catalyst for Biginelli-type reaction under the solvent-free condition
Author/Authors :
Omarzehi Chahkamali, Farhad Department of chemistry - University of Sistan and Baluchestan, Zahedan, Iran , Faghihi, Mohammad Reza Department of chemistry - University of Sistan and Baluchestan, Zahedan, Iran , Maghsoodlou, MalekTaher Department of chemistry - University of Sistan and Baluchestan, Zahedan, Iran
Abstract :
In this paper, a simple and highly efficient protocol for the synthesis of tetrahydropyrimidine-5-carboxamide has been reported usingLa(NO3)3.6H2O as catalyst under solvent-free conditionat 80°C. This method offers several advantages such as short reaction times, no waste formation,eco-friendliness, simple purification steps and high yield. In this work, six derivatives of pyrimidinone have been synthesized for the first time. These newly synthesized derivatives were characterized by 1HNMR and 13CNMR techniques.
Keywords :
Biginelli-type reaction , Tetrahydropyrimidine-5-carboxamide , La(NO3)3.6H2O , Solvent-free
Journal title :
Astroparticle Physics
