Synthesis of 2-amino-4H-chromene derivatives by three-component condensation using an amino acid as a suitable and useful catalyst under solvent-free and thermally conditions

An efficient, clean and one-pot procedure for the synthesis of 2-amino-4H-chromenes has been developed by three-component condensation of aldehyde derivatives, malononitrile, and 1- or 2-naphthol in the presence of aspartic acid as an amino acid and efficient catalyst under solvent-free and thermally conditions. Aspartic acid is one of two acidic amino acids. Aspartic acid is alanine with one of the β hydrogens replaced by a carboxylic acid group. The solvent-free conditions, a simple, efficient, and eco-friendly method, short reaction time and excellent yields of the products make this methodology highly significant.