Thermodynamic, spectral and antimicrobial activity of inclusion complexes of acridone and its oxime with β-cyclodextrin

One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is to form inclusion complexes with β-cyclodextrin. The formation of such complexes has been confirmed by changes in spectral characteristics and melting point data. The aqueous phase solubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The study of thermodynamic parameters like ΔG, ΔH, ΔS indicates the inclusion complex formation to be exothermic and spontaneous. The study of antimicrobial activity of these compounds indicates that the microbes like E. coli and P. aeruginosa are susceptible and the susceptibility increases significantly after formation of inclusion complex.