Microwave assisted oxidation coupling of thiols to symmetrical disulfides with tripropylammonium fluorochromate (VI) (TPAFC)

Tripropylammonium fluorochromate(VI) (TPAFC), is an efficient and new reagent, which is prepared easily and oxidizes thiols to the corresponding disulfides, quickly. The reactions are performed cleanly and are controlled to stop at the disulfide stage, without over-oxidation and side products. Coupling of thiols to their corresponding disulfides, are studied in solution at room temperature and in solution under microwave radiation. The easy procedure, simple workup, short reaction times, and excellent yields, are another advantages of this reagent.