Title of article :
Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors
Author/Authors :
Doulah, Abdolhassan Department of Nursing - Faculty of Nursing and Midwifery - Islamic Azad University - Ahvaz Branch , Mirzaei, Masoud Department of Chemistry - School of Sciences - Ferdowsi University of Mashhad , Nikpour, Mohsen Department of Chemistry - School of Sciences - Islamic Azad University - Ahvaz Branch , Farbood, Yaghoub Physiology Research Center and Department Physiology - Medicine Faculty - Ahwaz Jondishapour University of Medical Sciences, Ahwaz
Abstract :
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with
dimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-
e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with
secondary amines in boiling ethanol to afford the related 7-amino derivatives.
Keywords :
1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine , Dimethylthio carbamoylchloride , Pyrimidothiadiazine , Cyclocondensation
Journal title :
Astroparticle Physics
