Title of article :
Synthesis of a carbon-14 analogue of N-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14C] and its derivatives as NR2B-selective NMDA receptor antagonist
Author/Authors :
Saemian, Nader Radioisotope section / Nuclear science Research School - Nuclear Science and Technology Research Institute , Esmailli, Kameh Radioisotope section / Nuclear science Research School - Nuclear Science and Technology Research Institute , Shirvani, Gholamhossein Radioisotope section / Nuclear science Research School - Nuclear Science and Technology Research Institute , Javaheri, Mohsen Radioisotope section / Nuclear science Research School - Nuclear Science and Technology Research Institute , Khalili Arjomandi, Omid Radioisotope section / Nuclear science Research School - Nuclear Science and Technology Research Institute
Abstract :
Four amidine NR2B-selective NMDA receptor antagonists, N-( 2-methoxy benzyl) -3- phenyl-acrylamidine, N-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, N-benzyl- 3-phenyl-acryl amidine and N- duterio(phenyl)methyl]-3-phenyl-acrylamidine, all four labeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence from
Ba14CO3.
Keywords :
NMDA-receptor , Carbon-14 , Labeling , Amidines
Journal title :
Astroparticle Physics
