Author/Authors :
Andonian, L Dept. of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences , Mohammad, K Dept. of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences , Holakouie Naieni, K Dept. of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences , Bayatian, P Dept. of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences , Rezaie, S Division of Molecular Biology, Dept. of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences , Margaryan, A Human Genetics Group - Institute of Molecular Biology - National Academy of Sciences, Yerevan, Armenia , Yepiskoposyan, L Human Genetics Group - Institute of Molecular Biology - National Academy of Sciences, Yerevan, Armenia , Farhud, DD School of Public Health - Tehran University of Medical Sciences, Tehran , Khorramizadeh, MR Dept. of Medical Biotechnology - School of Advanced Medical Technologies - Tehran University of Medical Sciences, Tehran , Sanati, M H National Institute for Genetic Engineering and Biotechnology - Tehran
Abstract :
Background: The main goal of this study was to conduct a comparative population genetic study of Turkish speaking
Iranian Azeris as being the biggest ethno-linguistic community, based on the polymorph markers on Y chromosome.
Methods: One hundred Turkish-speaking Azeri males from north-west Iran (Tabriz, 2008-2009) were selected based
on living 3 generations paternally in the same region and not having any relationship with each other. Samples were
collected by mouth swabs, DNA extracted and multiplex PCR done, then 12 Single Nucleotide Polymorphisms (SNPs)
and 6 Microsatellites (MS) were sequenced. Obtained data were statistically analyzed by Arlequin software.
Results: SNPs and Microsatellites typing were compared with neighboring Turkish-speaking populations (from Turkey
and Azerbaijan) and Turkmens representing a possible source group who imposed the Turkish language during 11-15th
centuries AD. Azeris demonstrated high level of gene diversity compatible with patterns registered in the neighboring
Turkish-speaking populations, whereas the Turkmens displayed significantly lower level of genetic variation. This rate
of genetic affiliation depends primarily on the geographic proximity.
Conclusion: The imposition of Turkish language to this region was realized predominantly by the process of elite
dominance, i.e. by the limited number of invaders who left only weak patrilineal genetic trace in modern populations of
the region.
Keywords :
Iranian Azeris , Y chromosome diversity , Microsatellites , SNPs , Iran
