Author/Authors :
Tee, SF Dept. of Chemical Engineering - Faculty of Engineering and Science - Universiti Tunku Abdul Rahman (UTAR), Kuala Lumpur, Malaysia , Tang, PY Dept. of Chemical Engineering - Faculty of Engineering and Science - Universiti Tunku Abdul Rahman (UTAR), Kuala Lumpur, Malaysia , Loh, HC Dept. of Chemical Engineering - Faculty of Engineering and Science - Universiti Tunku Abdul Rahman (UTAR), Kuala Lumpur, Malaysia
Abstract :
Background: Molecular components of the dopamine receptor (DRD3) play an important role in the pathophysiology of
schizophrenia (SCZ). Previous studies have demonstrated an association between the DRD3 Ser9Gly polymorphism and
SCZ but the results have been inconclusive.
Method: In this study, we investigated this controversial association between the Ser9Gly (A/G) polymorphism and SCZ
using Malay cases-control (261 cases/157 controls) samples. PCR-RFLP was performed to genotype the distribution of
the DRD3 Ser9Gly polymorphism.
Results: Both healthy control and SCHZ patient groups were in of Hardy-Weinberg equilibrium for the analyzed genetic
variability. There was a significant association between the genotype distribution DRD3 polymorphisms and SCZ (χ2=
9.359; df = 2; P = 0.009).
Conclusion: We believe that further studies are required to examine the association between others dopamine-related
genes and the behavioral phenotypes of SCZ.
Keywords :
Schizophrenia , Dopamine receptor , Single nucleotide polymorphism , Restriction fragment length polymorphism
