Author/Authors :
Wang, HC Dept. of Hematology - Qilu Hospital - Shandong University, China , Shao, N Dept. of Hematology - Qilu Hospital - Shandong University, China , Zhang, JR Dept. of Hematology - Qilu Hospital - Shandong University, China , Zou, J Dept. of Hematology - Qilu Hospital - Shandong University, China , Ji, CY Dept. of Hematology - Qilu Hospital - Shandong University, China , Lin, HL School of Public Health and Primary Care - the Chinese University of Hong Kong - China
Abstract :
Background: A case-control study was carried out to investigate the roles of prior allergies and family history of
cancers and their interaction in the etiology of adult leukemia.
Methods: Prior allergies status and family history of cancers in first-degree relatives were compared between 131
incident leukemia cases and 206 hospital-based controls. Odds ratios (OR) were estimated using an unconditional
regression model taking into account potential confounding factors.
Results: Significant association between adult leukemia and prior allergies and family history of cancer (OR=2.09, 95%
CI: 1.22-3.58 for prior allergies; and OR=2.35, 95% CI: 1.09-5.03 for family history of cancer, OR=15.88, 95% CI:
1.77-142.55 for both the two factors (+), respectively) was found after adjusting for potential confounding factors.
Conclusion: Prior allergies and family history of cancers may be risk factors for adult leukemia; their interaction was
likely to be synergistic rather than additive for the risk of leukemia.
Keywords :
Leukemia , Prior allergies , Family history of cancers , Case-control study , China
