The Efficacy and Safety of Sesame Oil in Prevention of Chemotherapy-Induced Phlebitis in Children with Acute Lymphoblastic Leukemia

Background: Phlebitisis is the inflammation of the veins that negatively affect the patient’s health status. This study was conducted to determine the effect of external use of sesame oil in prevention of chemotherapyinduced phlebitis in children with ALL. Materials and Methods: This double-blind clinical trial was conducted on 60 patients aged 2 to 14 years old who were admitted for chemotherapeutic management to the 17th Shahrivar Hospital, Rasht, Iran, between January 2016 and January 2017.The patients were randomly divided into two groups: intervention and control. Ten drops of sesame oil in the sesame oil group and10 drops of oral liquid paraffin in the control group were given daily for 30 days. Data collection tools were run in both groups: a demographic questionnaire and the Visual Infusion Phlebitis Scale for the measurement of phlebitis. Data were analyzed using SPSS (version 23). Results: The survival time for vein received chemotherapy in the sesame oil group was 44%.The results of the present study showed that there is statistically significant difference between the mean grade of phlebitis in both groups (p = 0.0001).The relative risk of phlebitis incidence was two times more than the sesame oil group. Conclusion: External use of sesame oil can be effective in the prevention of chemotherapy-induced phlebitis.