Title of article :
The Efficacy of Vitamin E and Folic acid on the Acute Hemolysis Caused by Glucose-6 phosphate Dehydrogenase
Author/Authors :
Darbandi, Bahram Pediatrics Growth Disorders Research center - 17 shahrivar Pediatric Hospital - School of Medicine - Guilan University of Medical Sciences, Rasht, , Zarezadeh, Sharareh Pediatrics Growth Disorders Research center - 17 shahrivar Pediatric Hospital - School of Medicine - Guilan University of Medical Sciences, Rasht, , Hassanzadeh Rad, Afagh Pediatrics Growth Disorders Research center - 17 shahrivar Pediatric Hospital - School of Medicine - Guilan University of Medical Sciences, Rasht, , Baghersalimi, Adel Pediatrics Growth Disorders Research center - 17 shahrivar Pediatric Hospital - School of Medicine - Guilan University of Medical Sciences, Rasht, , Atrkar Roshan, Zahra School of Medicine - Guilan University of Medical Sciences, Rasht
Abstract :
Background: Glucose-6 phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme
deficiency of red blood cells involving the enzyme pathway of hexose monophosphate. This study was
conducted to examine the effect of vitamin E and folic acid on the improvement of acute hemolysis caused by
the G6PD deficiency in patients referred to 17 Shahrivar Hospital, Rasht.
Materials and Methods: This was a randomized clinical trial conducted on 120 patients with G6PD deficiency.
The patients were divided in 4 groups, including vitamin E, folic acid, a combination of both supplements, and
control groups. The hemoglobin level and the reticulocyte count of patients during hospitalization, at discharge
and two weeks after discharge were evaluated. All patients received standard treatment for acute hemolysis.
Results: Mean age of the patients was 44.19± 16.43 months. There was no significant difference between 4
groups in terms of age, gender, and etiology of hemolysis (p>0.05). The consumption of fava bean was the main
cause of hemolysis in 95% of patients. The level of hemoglobin and hematocrit, and reticulocyte count during
hospitalization and discharge among groups showed no significant difference (p>0.05). However, a significant
increase was observed in the level of hemoglobin and hematocrit and reduction of reticulocyte count in patients
receiving supplements compared with control group (p=0.001).
Conclusion: Considering the low cost, availability, and safety profile of theses supplements, it seems that usage
of folic acid and vitamin E can be highly recommended during favism
Keywords :
Favism , Folic Acid , Vitamin E , Hemolysis , Glucose-6 phosphate dehydrogenase
Journal title :
Astroparticle Physics