Langerhans cell histiocytosis of the clavicle in a 10-years-old girl

Langerhans cell histiocytosis (LCH) is an abnormal proliferation of Langerhans cells in one or more organs; bone is the most frequently involved organ in which the skull is the most frequent .The clavicle is rarely the primary site of the LCH, thereby the timely diagnosis is often delayed and most of the patients are primarily treated for acute or chronic osteomyelitis. Herein we report a 10 years old girl with swelling and pain in the medial end of the left clavicle admitted in Aliasghar Children’s Hospital in 2015 and final diagnosis of the LCH which was initially misdiagnosed as osteomyelitis. The LCH should be considered in the differential diagnosis of any lytic or destructive lesion of the clavicle for timely diagnosis and prevention of inappropriate treatment. Clavicle; Histiocytosis, Langerhans cell histiocytosis, Osteomyelitis, Pediatrics