Author/Authors :
Ayatollahi, Hossein Department of Hematology and Blood Bank - Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Sadeghian, Mohammad Hadi Department of Hematology and Blood Bank - Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Keshavarzi, Aref Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Shams, Behnaz Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Amirpour, Mojgan Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Sheikhi, Maryam Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Amini, Nafise Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Khiabani, Alireza Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences, Mashhad , Barzegar, Mohyedin Department of Hematology - ShahidBeheshti University of Medical Sciences, Tehran
Abstract :
Background: Acute Myeloid Leukemia (AML) is a group of heterogeneous malignancies caused by defects in
differentiation of hematopoietic cells. SRY-box containing gene 17(SOX17) is a transcription factor which
plays an important role in several biological processes, including cardiogenesis, angiogenesis, and
lymphopoiesis. Aberrant expression of SOX17 has been detected in solid tumors. This study was performed to
investigate the alternations of SOX17 expression in AML patients.
Materials and methods: This case-control study included 54 AML patients who were referred to Molecular
Pathology Cancer Research Center of Ghaem Hospital in North East of Iran from October 2011 to May 2016.
Patients were classified according to French-American-British (FAB) and World Health Organization (WHO)
criteria. RNA was extracted from peripheral blood. SOX17 gene expression was evaluated by real-time
quantitative polymerase chain reaction (RQ-PCR).
Results: Over expression of SOX17 was observed in 34 (62.96%) AML patients. No relation was noticed
between SOX17 expression and patient survival (p=0.493). In addition, no correlation among patient survival,
Sex(p=0.322),hemoglobin(p=0.866) and white blood cell (WBC) (p=0.103).
Conclusion: Based on these results, SOX17 did not have any important role in AML pathogenesis. Thus, it
can’t be used as a diagnostic and prognostic factor. However, more studies are required to fully elucidate the
role of SOX17 in AML.
