Simultaneous Pattern Visual Evoked Potential and Pattern Electroretinogram in Strabismic and Anisometropic Amblyopia

Background: Amblyopia is a relatively common condition in which visual acuity through an eye is subnormal despite no overt pathology. Pattern visual evoked potential (PVEP) can detect any defect from optic nerve to occipital cortex and pattern electroretinogram (PERG) can detect retinal defects specially the ganglion layers. This study was performed to evaluate the cortical and retinal activity in strabismic and anisometropic amblyopia. Methods: PVEP and PERG were recorded simultaneously in 40 amblyopes (20 strabismics and 20 anisometropics) and 20 normal control subjects. Normal subjects were age and sex matched with patients. Results: The P100 latency in PVEP was increased in both groups of patients but the P100 amplitude was reduced only in anisometropic group. In PERG, the amplitude of P50 was reduced in all patients with no significant change in latency. Conclusion: Beside reduced PVEP responses in strabismic and anisometropic amblyopia, the activity of retina reduced too. It is likely that retinal impulses can affect the development of visual system.