Author/Authors :
Beigi, AA Department of Vascular Surgery - Isfahan University of Medical Sciences , Sadeghi, AM Department of Surgery - Kashan University of Medical Sciences, Kashan, Iran , Masoudpour, H Department of Surgery - Isfahan University of Medical Sciences , Shirazinejad, S Department of Radiology - Isfahan University of Medical Sciences - Alzahra Hospital, Isfahan , Mottaghi, P Department of Internal Medicine - Isfahan University of Medical Sciences - Alzahra Hospital, Isfahan, Iran
Abstract :
Background: Based on beneficial reports of pamidronate use for reflex sympathetic dystrophy in reduction of
pain and swelling, this drug can be studied as a novel treatment for refractory lymphedema. This study aims to
determine the effectiveness of pamidronate on lymphedema and its possible side effects.
Methods: Twelve cases of lower limb refractory lymphedema were enrolled. They received intravenous pamidronate
monthly for 3 consecutive months and were followed by measuring any discomfort with visual analog
scale (VAS) and physician global assessment, based on objective signs of limb volume and circumference.
Results: The limb volume, circumference, and satisfaction of the patients improved significantly.
Conclusion: Pamidronate when is added to conservative treatments may reduce lymphedema and improve the
patient’s comfort.
