Author/Authors :
Mehrabani, D Stem Cell and Transgenic Technology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Ashraf, MJ Stem Cell and Transgenic Technology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Tanideh, N Stem Cell and Transgenic Technology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Ziaei, M Laparascopy Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Amini, M Laparascopy Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Hosseini, SV Colorectal Disease Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Ghahramani, L Colorectal Disease Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Bananzadeh, AM Colorectal Disease Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Amini, A Department of Anesthesiology - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Background: In patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosa
has been reported to increase the risk of colon cancer. So, a safe and efficient therapy is required for the
treatment and prophylaxis for the disease.This study aims to investigate the efficacy of Calendula officinalis
extract in treatment of experimentally induced ulcerative colitis in dog animal model.
Methods: During fall 2010, 10 out-bred female German dogs (1-2 years old; weighs of 20-25 kg) were enrolled.
Ulcerative colitis was induced with 6% acetic acid as enema and method of treatment was retrograde (via enema)
too by C. officinalis.
Results: Loose stools, diarrhea, gross bleeding and loss of body weight happened after administration of acetic
acid and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells were
noticed histologically. C. officinalis could successfully resolve the damages of UC.
Conclusion: Treatment with C. officinalis can broaden the current therapy options for UC.
Keywords :
Ulcerative colitis , Acetic acid , Calendula officinalis , Therapy , Dog
