Author/Authors :
Farzin, M Department of Prosthodontics - Dental School - Shiraz University of Medical Sciences, Shiraz, Iran , Mardani, M Department of Oral Medicine - Dental School - Shiraz University of Medical Sciences, Shiraz, Iran , Mardani, M Department of Oral Medicine - Dental School - Shiraz University of Medical Sciences, Shiraz, Iran , Ghabanchi, J Department of Oral Medicine - Dental School - Shiraz University of Medical Sciences, Shiraz, Iran , Rezaee, M Department of Oral Medicine - Dental School - Shiraz University of Medical Sciences, Shiraz, Iran , Fattahi, MJ Shiraz Institute for Cancer Research - Shiraz University of Medical Sciences, Shiraz, Iran , Heydari, ST Health Policy Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Andisheh Tadbir, A Department of Oral Pathology - Dental School - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Background: Oral Lichen planus (OLP) is a chronic lesion of the oral mucosa with unknown origin. Basement
membrane changes are common in OLP and may be mediated by proteases such as matrix metalloproteinase
(MMPs) and mast cell chymase. The aim of our study was to evaluate the level of serum MMP-3 in OLP compared
to normal individuals and assess its clinical significance.
Methods: Thirty four serum samples from patients diagnosed with OLP (12 males, 22 females, age: 42.2±10.8
years) and 34 serum samples from healthy control subjects (11 males, 23 females, age: 42.5±13.3 years) were
collected and MMP-3 concentration was measured by ELISA.
Results: The serum MMP-3 level in OLP patients was higher (21.64±24.31 ng/ml) compared with healthy controls
(16.52±23.63 ng/ml), but showed no statistically significant difference. A statistically significant difference
was demonstrated between the two types of OLP, being more pronounced in the erosive/atrophic form 6).
Conclusion: The different clinical appearances of OLP are associated with significant differences in MMP-3
serum level.
