Author/Authors :
Ashkani-Esfahani, S Shiraz University of Medical Sciences, Shiraz, Iran , Imanieh, MH Shiraz University of Medical Sciences, Shiraz, Iran , Meshksar, A Shiraz University of Medical Sciences, Shiraz, Iran , Khoshneviszadeh, M Shiraz University of Medical Sciences, Shiraz, Iran , Noorafshan, A Shiraz University of Medical Sciences, Shiraz, Iran , Geramizadeh, B Shiraz University of Medical Sciences, Shiraz, Iran , Ebrahimi, S Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Background: Finding more efficient agents with fewer side effects for treatment of burns has always been a
concern for researchers. Silver sulfadiazine (SSD), apparently due to its antimicrobial effect, is still one of the
most common prescribed agents. Previous studies suggested that Arnebia euchroma (AE) has shown antimicrobial
and anti-inflammatory activities. This study investigates the healing effect of AE extract in comparison with
SSD in second degree burn wounds.
Methods: Fort eight female Wistar rats (220±20 g) were divided into four groups. Standard second degree burn
wounds were induced on the back of their necks. One group was treated with SSD; two groups were treated with
AE cream at concentrations of 10% (AE10) and 20% (AE20) and the control group which received no treatment.
The duration of treatment was 28 days.
Results: This study revealed that AE and SSD noticeably improved re-epithelization, fibroblasts proliferation,
and collagen bundle synthesis and had a noticeable anti-inflammatory effect compared with the control group.
Conclusion: Results of the present study revealed that Arnebia euchroma herbal extract was an effective treatment
for second degree burn wounds when compared with SSD.
Keywords :
Healing , Arnebia euchroma , Burn , Wound , Rat
