Author/Authors :
Tavakol Afshari, Jalil Immunology Research Group - Faculty of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Shapouri-Moghaddam, Abbas Immunology Research Group - Bu-Ali Research Institute - Mashhad University of Medical Sciences - Mashhad, Iran , Ehteshamfar, Seyyed-Morteza Immunology Research Group - Bu-Ali Research Institute - Mashhad University of Medical Sciences - Mashhad, Iran , Saeed Modaghegh, Mohammad-Hadi Vascular and Endovascular Surgery Research Center - Alavi Hospital - Mashhad University of Medical Sciences, Iran , Rahimi, Hamid reza Department of Modern Sciences and Technologies - Faculty of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran
Abstract :
Thromboangiitis obliterans (TAO) is a thrombotic-occlusive as well as an inflammatory peripheral
vascular disease with unknown etiology. Recent evidence has supported the immunopathogenesis
of the disease, however, the factors contributing to the altered immune function and vascular tissue
inflammation are still unclear. This review was intended to collate the more current knowledge on the
regulatory molecules involved in TAO from an immunoreactive perspective. The homeostasis of the
immune system as well as a variety of progenitor cell populations appear to be affected during TAO
and these alterations are associated with intrinsic signaling defects that are directing to an improved
understanding of the crosstalk between angiogenesis and the immune system, as well as the potential
of new co-targeting strategies applying both immunotherapy and angiogenic therapy.
Keywords :
Angiogenesis , Immune system , Molecular biology , Signal pathways , Thromboangiitis obliterans
