Evaluation of the effect of Artemisia Sieberi mouthwash 1% on denture stomatitis (A preliminary study)

Background: Artemisia is a herbal plant that its anticandidal effect has been investigated in different studies. The aim of this study was to assess the effect of Artemisia sieberi mouth wash on denture stomatitis. Methods: This double blind clinical trial study was performed on 30 patients with denture stomatitis (type II, III). They were randomly divided into two groups. The patients in control group were asked to use Nystatin mouth wash 500,000IU qid and the patients of case group were asked to use Artemisia mouth wash 1% qid. The patients were visited weekly up to 1 week after complete resolution of stomatitis. In each visit, smears and cultures were provided, candida colony counts were performed and candida identification tests were done. Analyses of the data were done by Friedman, Chi-square and Mann Whitney tests. Results: All patients showed complete clinical healing after 1 week (in the second visit) except for 1 patient in each group who was healed after 2 weeks. There were no statistically significant differences in healing time between the two groups. Conclusion: The results show that the extract of Artemisia Sieberi1% could be effective on the treatment of denture stomatitis.