Author/Authors :
Farzaei, Mohammad Hosein Pharmaceutical Sciences Research Center - Kermanshah University of Medical Sciences - Kermanshah, Iran , Farzaei , Fatemeh Pharmaceutical Sciences Research Center - Kermanshah University of Medical Sciences - Kermanshah, Iran , Abbasabadi, Zahra Pharmaceutical Sciences Research Center - Kermanshah University of Medical Sciences - Kermanshah, Iran , Kahkeshani, Niloofar Department of Pharmacognosy - Faculty of Pharmacy - Hormozgan University of Medical Sciences - Bandar Abbas, Iran , Fotouhi, Maryam Student Research Committee - Faculty of Medicine - Iran University of Medical Sciences - Tehran, Iran , Alavi, Seyedeh Shaghayegh Department of Food Science - Engineering and Technology - Faculty of Agricultural Engineering and Technology - University of Tehran - Karaj, Iran , Bahramsoltani, Roodabeh Department of Pharmacy in Persian Medicine - School of Persian Medicine - Tehran University of Medical Sciences - Tehran, Iran , Naseri, Rozita Faculty of Medicine - Kermanshah University of Medical Sciences - Kermanshah, Iran , Momtaz, Saeideh Toxicology and Diseases Group - The Institute of Pharmaceutical Sciences - Tehran University of Medical Sciences - Tehran, Iran , Rahimi, Roja Department of Pharmacy in Persian Medicine - School of Persian Medicine - Tehran University of Medical Sciences - Tehran, Iran , Bishayee, Anupam Lake Erie College of Osteopathic Medicine - Bradenton - FL 34211, USA
Abstract :
Gallic acid is a natural phenolic compound found in several fruits and medicinal plants. It is
reported to have several health-promoting effects. This review aims to summarize the pharmacological
and biological activities of gallic acid in vitro and animal models to depict the pharmacological status
of this compound for future studies.
Materials and Methods: All relevant papers in the English language were collected up to June 2018. The
keywords of gallic acid, antioxidant, anticancer, antimicrobial, gastrointestinal-, cardiovascular-, metabolic-,
neuropsychological-, and miscellaneous- diseases were searched in Google Scholar, PubMed, and Scopus.
Results: Several beneficial effects are reported for gallic acid, including antioxidant, anti-inflammatory,
and antineoplastic properties. This compound has been reported to have therapeutic activities in
gastrointestinal, neuropsychological, metabolic, and cardiovascular disorders.
Conclusion: Current evidence confirms the pharmacological and therapeutic interventions of gallic
acid in multiple health complications; however, available data are limited to just cellular and animal
studies. Future investigations are essential to further define the safety and therapeutic efficacy of
gallic acid in humans.
Keywords :
Anticancer , Antioxidant , Gallic acid , Health benefits , Pharmacological effects
