Author/Authors :
Dadashi, Masoud Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Vaezjalali, Maryam Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Fallah, Fatemeh Pediatric Infections Research Center, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Goudarzi, Hossein Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Nasiri, Mohammad Javad Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Owlia, Parviz Molecular Microbiology Research Center - Shahed University, Tehran, IR Iran , Hashemi, Ali Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Darban-Sarokhalil, Davood Department of Microbiology - Faculty of Medicine - Iran University of Medical Sciences, Tehran, IR Iran
Abstract :
Background: Human papillomavirus (HPV) is one of the most common causes of sexually transmitted disease (STD) in humans. HPV is
associated with gynecologic malignancy and cervical cancer among women worldwide. In the current study we sought to determine the
prevalence rate of HPV in Iranian women identified with cervical infections.
Materials and Methods: Prevalence rate of HPV in Iran was investigated from 2000-2016 using several databases including Medline, Web
of Science, Embase, Google Scholar, Iranmedex, and Scientific Information Database. Statistical analysis was performed by Comprehensive
Meta-Analysis (V2.2, Biostat) software. Random effects models were used by taking into account the possibility of the heterogeneity between
the studies, which was tested through the Cochran’s Q-statistic.
Results: The meta-analyses showed that the prevalence rate of HPV infections was 38.6 % (95% CI, 27.9-50.5) among Iranian women with
cervical infections. The further stratified analyses indicated that the prevalence rate of HPV was higher in the studies conducted during the
2000-2008 years.
Conclusion: The results of the present study underscore the need for further enforcement of STD control strategies in Iran. Establishing
advanced diagnostic facilities for HPV, vaccination of high risk groups, and continuous monitoring of HPV are recommended for HPV
prevention and control.
Keywords :
Meta-analysis , Iran , Cervical infection , Human papillomavirus , HPV
