Title of article
In vitro Antibacterial Activity of Thymus vulgaris Essential Oil against Mycobacterium tuberculosis
Author/Authors
Pourazar Dizaji, Sh. Mycobacteriology & Pulmonary Research Department - Pasteur Institute of Iran, Tehran, Iran , Soleimani, N. Microbiology & Microbial Biotechnology Department - Life Sciences & Biotechnology Faculty - Shahid Beheshti University, Tehran, Iran , Afrugh, P. Mycobacteriology & Pulmonary Research Department - Pasteur Institute of Iran, Tehran, Iran , Saedi, S. Medical Bacteriology Department of Pasteur Institute of Iran, Tehran, Iran
Pages
5
From page
47
To page
51
Abstract
Aims Nowadays, treatment of bacterial infections is one of the most important challenges
in the world. Medicinal plants offer a great hope to overcome these needs because of their
chemical diversity and their significant role in the drug development. The aim of this study was
to evaluate the in vitro antibacterial activity of the thyme (Thymus vulgaris) essential oil against
Mycobacterium tuberculosis.
Materials & Methods In this experimental study, thyme herb plants were collected and
thyme essential oil was extracted. The Minimum Inhibitory Concentration (MICs) tests were
performed to determine the antimicrobial activity of Thymus plant against the first (Isoniazid,
Rifampicin, Ethambutol) and second (Cycloserine, Streptomycin, Kanamycin) drug antibiotics
of mycobacterium. Data were analyzed by SPSS 21 software, using one-way ANOVA test.
Findings The MICs for Isoniazid, Ethambutol, Streptomycin and Cycloserine were less than
10μg/ml and the MIC values for Rifampicin and Kanamycin were 40μg/ml. The limits of
minimal inhibitory concentration of essential oil was between 0.5-40μg/ml (p<0.05).
Conclusion Thyme essential oil has antibacterial activity against Mycobacterium tuberclusis.
Keywords
Thymus vulgaris , Antibiotic Resistance , Mycobacterium tuberculosis , Minimum Inhibitory Concentration
Journal title
Astroparticle Physics
Serial Year
2018
Record number
2442767
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