Author/Authors :
Mofid, B Dep. of Oncology - Shohada Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Jalali Nadoushan, MR Dep. of Pathology - Shahed University, Tehran , Rakhsha, A Dep. of Oncology - Shohada Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Mirzaei, HR Dep. of Oncology - Shohada Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Zeinali, L Dep. of Oncology - Shohada Hospital - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Background: The aim of this study was to evaluate over expression of epidermal
growth factor receptor (EGFR) gene in localized prostate cancers and determine
its relation with clinical and pathological factors affecting the progression of the
disease.
Methods: In the tissue samples of the patients with prostate cancer undergoing
radical prostatectomy, EGFR expression was evaluated by immunohistochemistry
technique. Those with scores 2 and 3 were considered to be positive for the
expression. The relation between gene expression and grade was evaluated by
chi-square test.
Results: Of 100 tissue samples evaluated, 80 and 20 had Gleason score (GS)
< 7 and ≥ 7, respectively. Also, 68 and 32 had PSA level ≤ 10 and >10,
respectively. A total of 59 samples were positive for EGFR expression, of whom,
46 had GS < 7 and 13 had GS > 7 (P-value = 0.39). Forty patients had
PSA < 10 and 19 had PSA > 10 (P-value = 0.5).
Conclusion: Fifty-nine percent of the patients with localized prostate cancer
undergoing radical prostatectomy were EGFR positive. No significant relation was
found between EGFR and grading (GS) or PSA.
