Author/Authors :
Noorian Noorian, Sajad Department of Statistics - Faculty of Scence - University of Qom - Qom, Iran , Moayeri, Hassan Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Esmaeil- Akbari, Mohammad Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Mirzaei, Hamid Reza Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Salati, Azam Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Khayamzade, Maryam Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Shormeij, Zeinab Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Shakeri, Jafar Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Nabatzadeh, Mojgan Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Shahani, Minoo Cancer Research Center - Shahid Beheshti University of Medical Sciences - Tehran, Iran , Nafissi, Nahid Medical Physics Department - Iran University of Medical Sciences - Tehran, Iran , Mahdavi, Seied Rabi Medical Physics Department - Iran University of Medical Sciences - Tehran, Iran , Kiaee, Marzieh Department of Optic and Photonic - Iran Telecom Research Center - Tehran, Iran
Abstract :
Background: Breast conserving surgery (BCS) and its following radiotherapy is an accepted therapeutic method for patients with
invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC).
Objectives: The aim of this study was to investigate the effect of intraoperative electron radiotherapy on women with breast cancer
(invasive lobular and ductal carcinoma).
Methods: Between August 2013 and September 2017, 968 patients, who were referred to Cancer Research Center, Shahid Beheshti
University of Medical Sciences with invasive breast cancer, were treated with breast-conserving surgery and radiotherapy. Of those,
426 patients received a tumor bed boost with intraoperative electron radiotherapy (IOERT) during lumpectomy (58 patients with
pure invasive lobular carcinoma, 239 patients with pure invasive ductal carcinoma, and 129 patients with other diagnoses). 542 patients
received a tumor bed boost with conventional external beam radiotherapy post lumpectomy (24 patients with pure invasive
lobular carcinoma, 418 patients with pure invasive ductal carcinoma, and 100 patients with other diagnoses). The patients were followed
up to 49 months. A comprehensive list of clinical and pathologic features was evaluated for all patients. We retrospectively
analyzed outcomes of breast cancer treated with boost intraoperative electron radiotherapy (pure ILC and IDC groups) and in other
group treated with boost conventional external beam radiotherapy (pure ILC group).
Results: None of the ILC patients had recurrence in the two groups. The four-year survival rate for ILC patients was 100%, but in
the IDC group the survival rate was 97%. Survival analyses showed patients with IDC had a higher risk of ipsilateral breast tumor
recurrence (IBTR) and metastasis.
Conclusions: Overall, the rates of IBTR and metastasis in the ILC boost IOERT group were significantly low. This finding suggests
that IOERT technique deployment in ILC had no inferiority compared with the control group.
Keywords :
IDC , ILC , Ipsilateral Breast Recurrence , IOERT
