Author/Authors :
Shaabani, Yousef School of Nutrition and Food Sciences - Shaheed Beheshti University of Medical Sciences, Tehran , Foroughi, Maryam School of Health - Teharan University of Medical Science, Tehran , Rastmanesh, Reza Department of Human Nutrition - School of Nutrition and Food Sciences, Tehran , Jamshidi, Ahmadreza Rheumatology Research Center - Teharan University of Medical Science , Tajik, Narges School of Health - Teharan University of Medical Science, Tehran , Assadi, Omid School of Nutrition and Food Sciences - Shaheed Beheshti University of Medical Sciences, Tehran
Abstract :
BACKGROUND: Elevated free radical generation in inflamed joints and impaired antioxidant
systems have been implicated in rheumatoid arthritis (RA). The present study was performed to
evaluate dietary nutrient intake and plasma oxidant status in RA patients.
METHODS: This case-control study comprised 75 RA patients and equal number of age- and
gender-matched controls. Nutrient intake was estimated by using a semi-quantitative food frequency
questionnaire. Blood samples were obtained from each group, and as an indicator of
oxidant status, plasma concentrations of malondiadehyde (MDA) were measured.
RESULTS: The mean calorie intake of RA patients was lower than that of the healthy controls.
Energy-adjusted intake of fat, vitamin A and ß-carotene were significantly lower in patients than
in control .Plasma MDA concentration was significantly higher in RA patients than in
controls (4.9±1.8 vs 2.1±0.6 nmoles/ml respectively,P < 0.01).
CONCLUSION: These results suggest proper antioxidant nutrient intake management may reduce
free radical generation and improve antioxidant status in RA patients.
