Author/Authors :
Emami-Razavi, S. H Experimental Laboratory -Cancer Research Center - Cancer Institute - Imam Khomeini Hospital - Tehran University of Medical Sciences , Esmaeili, N Experimental Laboratory -Cancer Research Center - Cancer Institute - Imam Khomeini Hospital - Tehran University of Medical Sciences , Forouzannia, S. K Department of Cardiovascular Surgery - Afshar Hospital - School of Medicine - Yazd University of Medical Sciences , Amanpour, S Experimental Laboratory -Cancer Research Center - Cancer Institute - Imam Khomeini Hospital - Tehran University of Medical Sciences , Rabbani, S Experimental Laboratory -Cancer Research Center - Cancer Institute - Imam Khomeini Hospital - Tehran University of Medical Sciences , Alizadeh, A. M Experimental Laboratory -Cancer Research Center - Cancer Institute - Imam Khomeini Hospital - Tehran University of Medical Sciences , Mohagheghi, M. A Experimental Laboratory -Cancer Research Center - Cancer Institute - Imam Khomeini Hospital - Tehran University of Medical Sciences
Abstract :
Wound healing in the skin depends upon the availability of appropriate trace metals as
enzyme cofactors and structural components in tissue repair. The present study is a part of a series of
experimental investigations to examine the influence of Bentonite on skin wound healing. Surgically
induced skin wounds in 48 young adult male rats were exposed topically to Bentonite (12 round wound
and 12 incisional wound) and control wounds (12 round wound and 12 incisional wound) received deionized
water only. Skin wounds (round and incisional) treated with Bentonite exhibited no significant
difference in margins with erythema and edematous changes. Scab and wound debris was more
extensive and persisted for at least 7 days after surgery in control group (P < 0.05). Skin wounds
exposed to Bentonite exhibited a mild retarded re-epithelialization, the treatment wounds were
characterized by a prominent central mass of inflammatory cells, cell debris and wound exudate. The
intense infiltrate of lymphocytes, macrophages, monocytes and fibroblasts extended from the wound
margin into the region of the panniculus carnosus muscle and hypodermis. Vascular dilatation and
dermal oedema were prominent features of these wounds. External utilization of Bentonite for wound
healing is safe and feasible, and we finalized that macroscopic healing of wound that treated by
Bentonite was superior versus control group.
