Author/Authors :
Zarei, Mahnaz Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Farahnak, Zahra Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Hosseinzadeh-Attar, Mohammad Javad Department of Clinical Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Javanbakht, Mohammad Hassan Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Hosseinzadeh, Payam Department of Nutrition and Biochemistry - The International Campus - Tehran University of Medical Sciences, Kish , Derakhshanian, Hoda Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Farahbakhsh-Farsi, Payam Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , Djalali, Mahmoud Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran
Abstract :
BACKGROUND: This study was designed to compare lipid peroxidation and antioxidant enzymes
activity in Type 2 diabetes patients with good or weak glycemic control.
METHODS: In this case-control study, 62 Type 2 diabetic patients with glycated hemoglobin
(HbA1c) between 6 and 8 were enrolled as the controlled group and 55 patients with HbA1c > 8
were selected as an uncontrolled group. Patients were all referred to Iranian Diabetes Association
in Tehran, Iran, from 2010 onward. Groups were chosen by convenience sampling and were
matched based on age, sex and duration of disease. Demographic questionnaire, two 24-hour food
recall, HbA1c, insulin, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase were
measured in blood samples. Data were analyzed by Food Processor II and SPSS software.
RESULTS: A mean daily consumption of energy, carbohydrate, protein, and fat was not
significantly different between two groups. MDA in the uncontrolled group was significantly
higher than controlled group (2.03 ± 0.88 vs. 1.65 ± 1.01 nmol/ml; P = 0.030). A mean SOD was
slightly higher in the uncontrolled group comparing to the control group
(843.3 ± 101.9 vs. 828.0 ± 127.3 U/g Hb; P = 0.400).
CONCLUSION: These data suggest that MDA as a lipid peroxidation indicator is higher in
uncontrolled diabetes probably due to chronic high blood sugar followed by higher oxidative stress.
