Author/Authors :
Kazemi-Saleh, Davoud Baqiyatallah University of Medical Sciences, Tehran , Koosha, Pooya Isfahan University of Medical Sciences, Isfahan , Sadeghi, Masoumeh Isfahan University of Medical Sciences, Isfahan , Sarrafzadegan, Nizal Isfahan University of Medical Sciences, Isfahan , Karbasi-Afshar, Reza Baqiyatallah University of Medical Sciences, Tehran , Boshtam, Mansoureh Isfahan University of Medical Sciences, Isfahan , Oveis-Gharan, Shahram Department of Neurology - School of Medicine - Tehran University of Medical Sciences, Tehran
Abstract :
BACKGROUND: Numerous studies have been conducted on the predictive effects of highsensitivity
C-reactive protein (hs-CRP) on cardiovascular events. Few studies have been
conducted to investigate the effects of adiponectin for the prediction of the incident of
cardiovascular events in the Middle East area. This study compared the predictive effect of hs-
CRP and adiponectin on healthy volunteers for the prediction of cerebrovascular disease (CVD).
METHODS: This nested case-control in original Isfahan Cohort Study (ICS) was conducted from
2001 to 2011. Participants were selected from ICS. The case group included participants with
CVD while the control group included participants without CVD. The level of hs-CRP and
adiponectin was measured in the blood samples collected in the year 2007. Thereafter, the
statistical analyses were performed to determine the predictive value of hs-CRP and adiponectin
in CVD prediction.
RESULTS: The results showed that before the elimination of diabetes effect; there was a
significant difference between the two groups, in terms of the mean of adiponectin (P = 0.019)
and no significant difference was observed in hs-CRP levels (P = 0.673). However, after
eliminating the factor of diabetes, there was no significant difference between the case and
control groups in adiponectin and hs-CRP levels (P = 0.184, P = 0.946). The results showed that
the odds ratio (OR) of the adiponectin level was 0.879 [95% confidence interval (CI): 0.719-
1.075, P = 0.210] while the or of hs-CRP was 1.045 (95% CI: 0.922-1.185, P = 0.491).
Furthermore, it was shown that after adjustment for age, sex, and diabetes; the or of
adiponectine was 0.875 (95% CI: 0.701-1.091, P = 0.235) and that of hs-CRP was 1.068 (95%
CI: 0.935-1.219, P = 0.333).
CONCLUSION: The results show that adiponectin and hs-CRP cannot be predictors for
cardiovascular events in a healthy population. Risk factors such as diabetes limit the use of
adiponectin as a CVD predictor.
