Author/Authors :
Gholoobi, Aida Department of Modern Sciences and Technologies - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Meshkat, Zahra Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Baghani, Akram Student Research Committee and Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Alavi, Maryam Sadat Cardiovascular Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Mohammadpoor, Toktam Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Momen-Heravi, Mastoureh Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Mouhebati, Mohsen Cardiovascular Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Sepahi, Samaneh Targeted Drug Delivery Research Center and School of Pharmacy - Mashhad University of Medical Sciences, Mashhad, Iran , Rostami, Sina Department of Biology - School of Sciences - Ferdowsi University of Mashhad, Mashhad, Iran , Meshkat, Mojtaba Mashhad Branch, Islamic Azad University, Mashhad, Iran , Gholoobi, Arash Atherosclerosis Prevention Research Center and Department of Cardiovascular Diseases - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
BACKGROUND: Although the role of enteroviruses has been proved in heart diseases, extensive information is not available on the association between enteroviruses and unstable angina. In the present study, the authors compared the prevalence of enteroviruses in patients with and without unstable angina. METHODS: Blood samples were taken from 51 patients with unstable angina and 55 patients without unstable angina or myocardial infarction that were admitted to Imam Reza and Ghaem hospitals (Mashhad, northeast of Iran). Reverse transcription polymerase chain reaction (RT-PCR) was performed using specific primers for the detection of the enteroviruses in blood samples of study subjects. RESULTS: Patients with and without unstable angina were similar in age with mean ± standard deviation of 62.6 ± 12.8 and 59.7 ± 12.7 years, respectively (P = 0.243) and there were no differences in gender in these two groups (P = 0.174). Prevalence of the enteroviruses in patients with unstable angina was higher only in 66-80 years age group compared to the control group (patients without unstable angina, P = 0.032). There was a higher prevalence of enterovirus RNA positivity in the blood samples of women with unstable angina (75.9%) than those without unstable angina (41.7%, P = 0.011), however, no significant difference was observed in men (P = 0.983). CONCLUSION: Our data showed that enteroviral RNA positivity was higher in patients with unstable angina compared to those without unstable angina. However, the differences between the two groups were not statistically significant.
