Title of article :
INTRATHECAL MIDAZOLAM PROLONGS THE ANALGESIC EFFECTS OF SPINAL BLOCKADE WITH LIDOCAINE FOR PERINEAL OPERATION
Author/Authors :
Jahangiri, B Department of Anesthesiology - Imam Khomeini Hospital - School of Medicine - Medical Sciences/University of Tehran , Jahangiri, R Department of Anesthesiology - Imam Khomeini Hospital - School of Medicine - Medical Sciences/University of Tehran
Abstract :
Intrathecal administration of midazolam has been reported to have antinociceptive action,
and to be an effective analgesic agent. In this prospective double-blind study we aimed to evaluate the
postoperative effects of intrathecal midazolam with lidocaine following perineal operation. Forty
patients were randomly allocated to two groups: 20 patients in the control group received 2 ml of 5%
heavy lidocaine plus 0.4 ml of 0.9% saline intrathecally; 20 patients in the midazolam group received 2
ml of 5% heavy lidocaine plus 0.4 ml of 0.5% midazolam. Duration of analgesia was significantly
greater in the midazolam group (7 ± 1 hours) compared to the control group (1.5 ± 0.5 hours).
Keywords :
Anesthetic techniques , lidocaine , benzodiazepine , intrathecal midazolam
Journal title :
Astroparticle Physics
