Title of article :
PATTERN OF INHERITANCE OF IDIOPATHIC HYPERCALCIURIA IN TWO FAMILIES
Author/Authors :
Nickavar, A Department of Pediatrics - Rasoul Akram Hospital - School of Medicine - Iran University of Medical Sciences, Tehran , Sharifian, M Department of Pediatrics - Mofid Children Hospital - School of Medicine - Shaheed Beheshti University of Medical Sciences, Tehran , Tabarroki, A Fellowship of Molecular Genetics - Day Hospital, Tehran
Abstract :
Idiopathic hypercalciuria is a leading cause of frequency-dysuria syndrome in childhood.
Different modes of inheritance have been suggested in this disease. This article presents the occurrence
of idiopathic hypercalciuria in all children of two families. In the first family, a 5.5 year old girl with a
history of renal stones and dysuria due to hypercalciuria, had two involved brothers and one sister. In
the second family, hypercalciuria and medullary nephrocalcinosis were detected in two siblings who
were admitted for polyuria and dysuria. Idiopathic type of hypercalciuria was diagnosed in these two
families by normal laboratory exams and exclusion of other causes of normocalcemic hypercalciuria.
According to the involvement of all offsprings (both sexes) in these two families, it is suggested that
idiopathic hypercalciuria is an autosomal dominant disease with complete penetration.
Keywords :
Idiopathic hypercalciuria , inheritance , childhood , autosomal dominant
Journal title :
Astroparticle Physics
