Title of article :
Effect of Magnetic Fluid Hyperthermia on Implanted Melanoma in Mouse Models
Author/Authors :
Mehdizadeh, Alireza Department of Medical Physics - School of Medicine - Shiraz University of Medical Sciences - Shiraz , Heidari, Maryam Department of Medical Physics - School of Medicine - Shiraz University of Medical Sciences - Shiraz , Sattarahmady, Naghmeh Department of Medical Physics - School of Medicine - Shiraz University of Medical Sciences - Shiraz , Zare, Tahereh Department of Medical Physics - School of Medicine - Shiraz University of Medical Sciences - Shiraz , Javadpour, Sirus Department of Materials Science and Engineering - School of Electrical and Computer Engineering, Shiraz University - Shiraz, , Azarpira, Negar Transplant Research Center - Department of Pathology - Namazee Teaching Hospital - Shiraz University of Medical Sciences - Shiraz , Heli, Hossein Department of Nanomedicine, School of Advanced Medical Sciences and Technologies - Shiraz University of Medical Sciences - Shiraz , Rajaei, Amirhossein Department of Electrical and Electronic - School of Electrical and Electronic Engineering - Shiraz University of Technology, Shiraz,
Abstract :
Background: Nowadays, magnetic nanoparticles (MNPs) have
received much attention because of their enormous potentials in
many fields such as magnetic fluid hyperthermia (MFH). The
goal of hyperthermia is to increase the temperature of malignant
cells to destroy them without any lethal effect on normal tissues.
To investigate the effectiveness of cancer therapy by magnetic
fluid hyperthermia, Fe0.5Zn0.5Fe2O4 nanoparticles (FNPs) were
used to undergo external magnetic field (f=515 kHz, H=100 G)
in mice bearing implanted tumor.
Methods: FNPs were synthesized via precipitation and
characterized using transmission electron microscopy (TEM),
vibrating sample magnetometer, and Fourier transform
infrared. For in vivo study, the mice bearing implanted tumor
were divided into four groups (two mice per group), namely,
control group, AMF group, MNPs group, and MNPs&AMF
group. After 24 hours, the mice were sacrificed and each tumor
specimen was prepared for histological analyses. The necrotic
surface area was estimated by using graticule (Olympus, Japan)
on tumor slides.
Results: The mean diameter of FNPs was estimated around
9 nm by TEM image and M versus H curve indicates that this
particle is among superparamagnetic materials. According to
histological analyses, no significant difference in necrosis extent
was observed among the four groups.
Conclusion: FNPs are biocompatible and have a good size for
biomedical applications. However, for MFH approach, larger
diameters especially in the range of ferromagnetic particles due
to hysteresis loss can induce efficient heat in the target region.
Keywords :
Hyperthermia , Induced , Nanoparticles , Magnetic fields , Melanoma , Mice
Journal title :
Astroparticle Physics
