Title of article
Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy
Author/Authors
Handjani, Farhad Molecular Dermatology Research Center, Shiraz University of Medical Sciences, , Yousef, Saeed Reza Molecular Dermatology Research Center, Shiraz University of Medical Sciences, , Saki, Nasrin Molecular Dermatology Research Center, Shiraz University of Medical Sciences, , Hamidizadeh, Nasrin Molecular Dermatology Research Center, Shiraz University of Medical Sciences,
Pages
5
From page
488
To page
492
Abstract
Pentavalent antimonials, as the 1st choice for the treatment of
cutaneous leishmaniasis (CL), have various side effects. Also,
there are some reports of drug resistance. Due to its safety,
cryotherapy can be a good alternative or complementary
treatment in CL. The aim of this study was to explore the
possible systemic immunological mechanisms of cryotherapy
besides its local effects in the treatment of CL. Twenty patients
with CL were selected. The disease was confirmed via a direct
smear. A venous blood sample was collected to determine IL-10
and IFN-γ levels before starting cryotherapy. Then, 1 week
after 8 sessions of cryotherapy were completed (i.e., 63 d), a
2nd venous sample was taken in order to compare the results
with the pretreatment levels of these cytokines using the ELISA
method. Cryotherapy resulted in no change in the levels of IL-10
and significantly increased the IFN-γ levels in our patients with
CL. Given these inconclusive or even mixed results, a larger
sample size is needed in order to better assess the systemic
immunological effects of cryotherapy.
Keywords
Leishmaniasis , Cutaneous , Interleukin-10 , Interferon-gamma
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2445337
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