Author/Authors :
Tabrizi, Reza Health Policy Research Center - Institute of Health - Student Research Committee, Shiraz University of Medical Sciences , Akbari, Maryam Health Policy Research Center - Institute of Health - Student Research Committee, Shiraz University of Medical Sciences , Heydari, Taghi Health Policy Research Center - Institute of Health - Student Research Committee, Shiraz University of Medical Sciences , Kamran B Lankarani Health Policy Research Center - Institute of Health - Student Research Committee, Shiraz University of Medical Sciences , Moosazadeh, Mahmood Health Science Research Center - Addiction Institute, Mazandaran University of Medical Sciences , Dabbaghmanesh, Mohammad Hossein Endocrine and Metabolism Research Center - Nemazee Hospital, Shiraz University of Medical Sciences , Mohamadkhani, Minoo Department of Epidemiology - School of Medicine, Rafsanjan University of Medical Sciences , Asemi, Zatollah Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Akbari, Mojtaba Department of Epidemiology - Faculty of Health, Shiraz University of Medical Sciences
Abstract :
Background: The prevention and correction of vitamin D
deficiency requires a precise depiction of the current situation
and identification of risk factors in each region. The present
study attempted to determine these entities using a systematic
review and meta-analysis in Iran.
Methods: Articles published online in Persian and English between
2000 and November 1, 2016, were reviewed. This was carried out
using national databases such as SID, IranMedex, Magiran, and
IranDoc and international databases such as PubMed, Google
Scholar, and Scopus. The heterogeneity index among the studies
was determined using the Cochran (Q) and I2 test. Based on the
heterogeneity results, the random-effect model was applied to
estimate the prevalence of vitamin D deficiency. In addition, metaregression
analysis was used to determine heterogeneity-suspected
factors, and the Egger test was applied to identify publication bias.
Results: The meta-analysis of 48 studies identified 18531
individuals with vitamin D deficiency. According to the randomeffect
model, the prevalence of vitamin D deficiency among
male, female, and pregnant women was estimated to be 45.64%
(95% CI: 29.63 to 61.65), 61.90% (95% CI: 48.85 to 74.96),
and 60.45% (95% CI: 23.73 to 97.16), respectively. The results
of the meta-regression analysis indicated that the prevalence
of vitamin D deficiency was significantly different in various
geographical regions (β=4.4; P=0.023).
