Title of article :
Pamidronate infusion improved two cases of intractable seronegative rheumatoid arthritise
Author/Authors :
Salesi, Mansour Assistant professor - Department of Rheumatology - School of Medicine, Isfahan University of Medical Sciences , Mottaghi, Peyman Assistant professor - Department of Rheumatology - School of Medicine, Isfahan University of Medical Sciences
Abstract :
Pamidronate is a bisphosphonate derivative that can inhibit bone resorption by actions on osteoclasts and increase bone
density in spite of treatment with steroids. This drug has the anti-inflammatory effect by increase apoptosis of monocytes.
5-10 percent of rheumatoid arthritis patients is seronegative and may be resistant to conventional disease modifying anti
rheumatic drugs (DMARDs). Intravenous (IV) pamidronate can be effective in disease control in seronegative rheumatoid
arthritis. We report two cases of seronegative and drug resistant rheumatoid arthritis that favorably responds to pamidronate
Keywords :
Pamidronate , Seronegative , Rheumatoid Arthritis
Journal title :
Astroparticle Physics
