Author/Authors :
Amiri, Mojgan Nutrition and Food Security Research Center - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Ghaneian, Mohammad Taghi Environmental Science and Technology Research Center - Department of Environmental Health Engineering - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Zare-Sakhvidi, Mohammad Javad Occupational Health Research Center - Department of Occupational Health - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Rahmanian, Masoud Diabetes Research Center - School of Medicine - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Nadjarzadeh, Azadeh Nutrition and Food Security Research Center - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Moghtaderi, Fatemeh Nutrition and Food Security Research Center - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Raeisi-Dehkordi, Hamidreza Nutrition and Food Security Research Center - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Zimorovat, Alireza Nutrition and Food Security Research Center - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Jafari, Fateme Nutrition and Food Security Research Center - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Zavar-Reza, Javad Department of Biochemistry - School of Medicine - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Jahan-Mihan, Alireza Department of Nutrition and Dietetics - University of North Florida, Jacksonville, FL, USA , Aghaei-Meybodi, Mohammad Reza Diabetes Research Center - School of Medicine - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Salehi-Abargouei, Amin Nutrition and Food Security Research Center - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract :
BACKGROUND: Both canola and sesame oils consumption have been associated with favorable
effects on cardio-metabolic biomarkers. However, to the best of our knowledge, no study has
compared their effects on cardiovascular risk factors. The present study aimed to assess the
effect of canola, sesame, and sesame-canola oils consumption on cardio-metabolic biomarkers
in patients with type 2 diabetes mellitus (T2DM ).
METHODS: This study was a randomized, triple-blind, three-way, crossover clinical trial. The
study participants included 102 individuals with T2DM . Their spouses were also included in the
study. The participants were entered into a 4-week run-in period. After that, their regular
dietary oil was replaced with canola, sesame, or sesame-canola oils (a blend of sesame and
canola oils) in three 9-week phases, which were separated by two 4-week washout periods
(sunflower oil was consumed during the run-in and the washout periods). Dietary, physical
activity, blood pressure, and anthropometric measurements were assessed at the beginning, in
the middle (week 4-5), and at the end of each treatment phase. Blood samples were taken at the
beginning and at the end of each phase. Serum, plasma, buffy coat, and whole blood samples
were extracted and kept at -80 ºC for further analysis. Serum fasting blood sugar (FBS),
triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) , and lowdensity
lipoprotein cholesterol (LDL-C) were selected as the primary outcomes.
RESULTS: 102 participants with T2DM were randomly assigned to one of the 6 rolling methods.
Through them, 93 individuals (91.2%) completely participated in all phases.
CONCLUSION: The present study will provide an exceptional opportunity to examine the effect of
canola, sesame, and sesame-canola oil on cardio-metabolic markers in adults with and without
T2DM . This trial will also provide a good medium for the investigation of gene-dietary oils
interaction in the future.
