Author/Authors :
Masoumi, Gholamreza Assistant Professor, Department of Cardiac Anesthesiology - Shahid Rajaee Hospital, Isfahan University of Medical Science , Hidarpour, Evaz Professor - Department of Cardiac Anesthesiology, Tehran University of Medical Science , Sadeghpour Tabae, Ali Assistant Professor - Department of Cardiac Surgery, Tehran University of Medical Science , Ziayeefard, Mohsen Assistant Professor - Department Of Anesthesiology, Tehran University of Medical Science , Azarasa, Atosa Assistant Professor - Department of Cardiac Anesthesiology, Ghazvin University of Medical Science , Abneshahidi, Amin Assistant Professor - Department of Anesthesiology, Isfahan University of Medical Science , Javid Anbardan, Sanam Medical Student, Tehran University of Medical Science , Kashefi, Parviz Asociated Professor - Department of anesthesiology, Isfahan University of Medical Science
Abstract :
BACKGROUND: Hemodynamic deterioration is a common postoperative problem. Intravenous nitroglycerin (NTG) is
used for prevention of this complication. Nitroglycerin has different doses and is primarily a vasodilator. Applying different
doses of intravenous NTG can induce different effects on post-operative cardiac instability, so we aimed to investigate
whether there was a difference need for administration of inotrope drugs in patients undergoing CABG as indicators
of cardiac instability.
METHODS: Sixty seven consecutive patients enrolled in this double-blind clinical trial performed in Shahid Rajaee hospital,
Shahid Beheshti University of Medical Science, Tehran, Iran.
RESULTS: The decrease in blood pressure and the need for administration of epinephrine was more prevalent in warming
up period in all three groups. No need for administration of epinephrine was detected before and during anesthesia
in groups receiving 100 and 150 μg/min intravenous nitroglycerin, but 6.6 percent (1 patient) of patients receiving 50
μg/min epinephrine, demonstrated a decrease in blood pressure which necessitated the use of epinephrine.
CONCLUSIONS: It seemed that application of different doses of intravenous nitroglycerin did not exert a significant influence
on cardiac instability and the need for use of inotrope drugs
