Author/Authors :
Heidarpour, Mitra Associate Professor - Department of Pathology, Isfahan University of Medical sciences , Rajabi, Parvin Professor - Department of Pathology, Isfahan University of Medical sciences , Sajadi, Farzaneh Resident, Department of Pathology, School of Mediine and Student Research Committee, Isfahan University of Medical Sciences, Isfahan
Abstract :
BACKGROUND: The distinction between basal cell carcinoma (BCC) and trichoepithelioma (TE) may be very difficult in
some cases because of the close similarities of these two lesions clinically and histopathologically. The purpose of this
study is to investigate the usefulness of CD10 in distinguishing BCC and TE.
METHODS: The immunohistochemical expression of CD10 was evaluated in an archived group of 30 BCCs and 12 TEs
in a retrospective cross sectional study. The localization of anti-CD10 to the tumoral and/or stromal cells was determined
in each case and was compared between these two tumors using Fisher's Exact Test.
RESULTS: In BCC cases, the expression of CD10 was noted in tumoral cells in 26 cases (83.2%). Of these, 3 cases
showed positivity of the stromal and basaloid cells, two cases demonstrated stromal expression alone and two BCCs
were not immunoreactive. On the other hand, 10 out of 12 (83.3%) TEs showed positive stromal immunoreactivity. Of
these, one case also showed positivity of the basaloid cells. One TE demonstrated epithelial expression alone and one
TE was not immunoreactive. The pattern of staining of basaloid cells and stromal cells in BCC and trichoepithelioma
was statistically different (p < 0.001).
