Author/Authors :
Shetab Boushehri, Vahid Department of Toxicology and Pharmacology - Faculty of Pharmacy & Nanotechnology Research Center - Tehran University of Medical Sciences , Ostad, Nasser Department of Toxicology and Pharmacology - Faculty of Pharmacy & Nanotechnology Research Center - Tehran University of Medical Sciences , Sarkar, Saeed Research Center for Science and Technology in Medicine (RCSTIM) - Tehran University of Medical Sciences , Kuznetsov, Dmitry A N.N. Semenov Institute for Chemical Physics - Russian Academy of Sciences - Moscow - Russian Federation , Buchachenko, Anatoly L Department of Chemistry - M.V. Lomonosov Moscow State University - Moscow, Russian Federation , Orlova, Marina A Department of Anatomy - School of Medicine - Tehran University of Medical Sciences , Minaii, Bagher Department of Anatomy - School of Medicine - Tehran University of Medical Sciences , Kebriaeezadeh, Abbas Department of Toxicology and Pharmacology - Faculty of Pharmacy & Nanotechnology Research Center - Tehran University of Medical Sciences , Rezayat, Mahdi Department of Medical Nanotechnology - Tehran University of Medical Sciences
Abstract :
This is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic
stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent
effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hrs after a single
injection (0.03 – 0.1 LD50). Magnesium magnetic isotope effect selectively stimulates the ATP formation in
the oxygen-depleted cells due to a creatine kinase (CK) and mitochondrial respiratory chain-focusing “attack”
of 25Mg2+ released by nanoparticles. These “smart nanoparticles” with membranotropic properties release
the overactivating cations only in response to the intracellular acidosis. The resulting positive changes in
the energy metabolism of heart cell may help to prevent local myocardial hypoxic (ischemic) disorders
and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-induced clinical
situations including DXR side effects.
Keywords :
Fullerene nanoparticles , doxorubicin-induced cardiotoxicity , 25Mg2+ , mitochondrial dysfunctions
