Title of article
Gabapentin: An update of its pharmacological properties and therapeutic use in epilepsy
Author/Authors
Honarmand, Azim Associate Professor of Anesthesiology - Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences , Safavi, Mohammadreza Associate Professor of Anesthesiology - Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences , Zare, Mohammad Associate Professor of Neurology - Department of Neurology, Isfahan University of Medical sciences
Pages
8
From page
1062
To page
1069
Abstract
The new antiepileptic medications are prescribed for the treatment of patients with seizure disorders since 17 years ago.
Gabapentin (GBP) was approved on January 1994 as adjunctive treatment in patients 12 years or older with partial seizures,
with or devoid of secondary generalization. GBP, was formerly known as an anticonvulsant γ-aminobutyric acid
(GABA) mimetic, is considered as a safe and well-tolerated antiepileptic drug (AED) with promising pharmacokinetic
properties and a wide therapeutic index. GBP is useful for the therapy of mixed seizure disorders and refractory partial
seizures in children. GBP must be regarded as the first treatment for older patients with recently diagnosed seizures.
GBP has a well recognized clinical efficacy in those types of focal epilepsy which were resistant to the traditional
AEDs. The main object of this review was to evaluate the efficacy, tolerability, dosing schedules and safety of GBP that
have been investigated in peer-reviewed journals.
Keywords
Antiepileptic drugs , efficacy , epilepsy , gabapentin , new antiepileptic drugs , seizures
Journal title
Astroparticle Physics
Serial Year
2011
Record number
2445956
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