Title of article :
Diagnostic values of Helicobacter pylori diagnostic tests: stool antigen test, urea breath test, rapid urease test, serology and histology*
Author/Authors :
Kazemi, Shadi Resident, Department of Internal Medicine, School of Medicine and Student Research Committee Isfahan University of Medical Sciences, Isfahan , Tavakkoli, Hamid Associate Professor - Department of Internal Medicine - School of Medicine, Isfahan University of Medical Sciences , Habizadeh, Mohamad Reza Anesthesiologist - Amin Hospital, Isfahan University of Medical Sciences , Emami, Mohammad Hasan Associate Professor - Department of Internal Medicine - School of Medicine, Isfahan University of Medical Sciences
Abstract :
BACKGROUND: The purpose of this study is to compare validity of 5 diagnostic tests of helicobacter pylori with each
other: stool antigen test, urea breath test (UBT), rapid urease test (RUT), serology and histology.
METHODS: A total of 94 patients who had indication of endoscopy entered the study. All of the 5 tests were performed
for each patient. When the results of at least 2 tests were positive (except serology), Helicobacter pylori infection was
considered to be positive. The sensitivity, specificity, positive predictive value, negative predictive value, accuracy and
area under receiver operating characteristic (ROC) curve of these 5 tests were determined.
RESULTS: The sensitivity, specificity, positive predictive value, negative predictive value, accuracy and area under ROC
curve of these 5 tests are as below, respectively. Histology: 89%, 78%, 93%, 91%, 85% and 0.881; RUT: 93%, 75%,
95%, 94%, 86% and 0.831; serology: 50%, 54%, 46%, 61%, 52% and 0.563; stool antigen test: 96%, 83%, 98%, 96%,
91% and 0.897; UBT: 89%, 73%, 92%, 90%, 82% and 0.892.
CONCLUSIONS: Stool antigen test is the most accurate test for Helicobacter pylori diagnosis before eradication of these
bacteria
